In my last article, "Anxiety," I promised to take next with the same disease drug therapies and a little more emotional. It has been shown that the drug, the implementation of emotional therapy yielded fruitful results for anxiety. Therefore consulted psychiatrists in the world to ask for their opinions and suggestions. With this in mind, I tried to highlight two treatment methods in this article for me. The first half of this article talks about effective drug that has been used by doctors for over a decade, while the second half is some useful treatments are discussed.
In the past, other classes of CNS-active drugs used to treat daytime sedation and anxiety. These drugs included propanediol carbamates (meprobamate especially), and barbiturates (see use for anxiety is now obsolete mainly because of their tendency to cause undesirable degree of sedation or intoxication Frank doses needed to relieve anxiety. meprobamate and barbiturates can also induce tolerance and physical dependence, withdrawal reactions severe and sometimes fatal overdose toxicity.
The antihistamine hydroxyzine is an effective sedative, but only at doses (about 400 mg per day) which produce marked sedation. Propranolol and metoprolol can lipophilic adrenoceptor antagonists entering the central nervous system, which reduces vegetative symptoms (anxiety and muscular tremor) are associated with situational phobias or social, but does not seem to be effective in trouble generalized anxiety or panic disorder.
Similarly, other adrenergic agents, including clonidine, modification autonomous expression of anxiety, but have not been convincing to be clinically useful in the treatment of severe anxiety disorders.
Another class of agents with positive effects on diseases characterized by anxiety or dysphoria is moderate azapirones (azaspirodecanediones), currently represented clinically by buspirone (Buspar). The azapirones limited antidopaminergic action in vivo and did not induce clinical extrapyramidal side effects. In addition, they do not interact with the benzodiazepine binding sites or facilitate the effects of GABA.
They are not anticonvulsant (and may even lower the seizure threshold something), does not cause reactions of tolerance or withdrawal and does not show cross-tolerance with benzodiazepines or other sedatives. Buspirone and several experimental congeners (eg, gepirone, ipsapirone and tiospirone) have a selective affinity for the serotonin receptor 5-HT1A type to which they appear to be partial agonists.
Buspirone has taken positive measures in anxious patients, especially those with generalized anxiety disorder of mild or moderate intensity. Unlike benzodiazepines and antidepressants strong, buspirone lack of positive measures in severe anxiety with panic attacks. It is not effective as monotherapy in obsessive-compulsive disorder, although it may be useful anti-compulsive activity in addition to SSRIs (which are effective as monotherapy).
The lack of cross-tolerance is consistent with the lack of clinical protection against withdrawal-emergent concern at the sudden transition from treatment with a benzodiazepine buspirone, a gradual transition between these classes of anxiolytics are more likely to be tolerated. Interestingly, the risk of suicide with buspirone very low.
The main limitation to the development of antidepressants and anxiolytics is a fundamental lack of a coherent pathophysiology and etiology of depression and anxiety common.
Despite a number of new products for treating depression or anxiety in development, including other inhibitors of neuronal transport of one or more monoamines, including norepinephrine or dopamine and serotonin (eg , milnacipran).
Serotonin agonists (eg sunepitron,), largely for anxiety, serotonin antagonists (eg deramciclane,), mainly for depression, agents with partial agonist effects of dopamine and serotonin, a bit like some atypical antipsychotics, inhibitors of MAO-A inhibitor (moclobemide, selegiline), inhibitors of phosphodiesterase 4, glutamate -amino-3-hydroxy-5-methyl-4-isoxazole receptor modulators propionic acid (AMPA) (Ampakines) metabotropic receptor agonists glutamate distress, GABAA receptor agonists anxiety (eg ocinaplon, pagoclone), inhibitors of neurokinin-1 (substance P) receptors, ligands for sigma-2 brain areas, corticotropin receptor antagonists and the methyl donor metabolic S-adenosyl-L-methionine.
As discussed above, these drugs with certain emotional transformation is necessary. If you find a patient to feel anxiety or emotional disturbance, you must change your daily routine and try to add something new that is interesting and attention-consuming for you. It helps to divert your attention from the targeted question. Something fun that you can do in my spare time you can benefit greatly.
Similarly, if you have a family some members begin to spend time with them because it will help you arrive at a normal emotional. Including a program picnic with some friends around or socialize with your colleagues for a dinner or lunch will be a good effect on your emotional distress. You can try it once a week if you're too busy to take time for yourself.
Try adding some form of daily physical activity into your schedule. You can add daily functioning, jogging, long walk or yoga, choose the one that suits you best. It works wonders if you continue to do this on a regular basis. It keeps the moral costs and brings you closer to nature. A society with nature can give you the best way to maintain emotional harmony. An excursion outside fresh air can lead to good results. For a moment, you forget everything and refresh your senses. It is suggested that psychiatrists each patient anxiety.
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